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Feature wish: --indep-r2 about plink-ng HOT 6 CLOSED

chrchang avatar chrchang commented on August 17, 2024
Feature wish: --indep-r2

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Comments (6)

chrchang avatar chrchang commented on August 17, 2024

A fully powered version of this (capable of using SHAPEIT's results, etc.) is planned for PLINK 2.0. I'll ask around and see if there's substantial demand for a "bad phasing" --indep-pairwise in v1.9, though.

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kforner avatar kforner commented on August 17, 2024

When you say "bad phasing", you mean a pairwise maximum-likelihood estimate of the phase as opposed to the shapeit algorithm that uses information from all snps I guess ?

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chrchang avatar chrchang commented on August 17, 2024

Correct. There's existing software which performs the more accurate r^2 computation (e.g. VCFtools --hap-r2), and one can write a script to select variants in an indep-pairwise-like manner using those results if the additional accuracy is important today.

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kforner avatar kforner commented on August 17, 2024

I just saw that you recommend to use the google group for feedback. Do you prefer that I post the feature request there for the record ?

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chrchang avatar chrchang commented on August 17, 2024

That's a good way to gauge additional interest in this feature, yes.

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kforner avatar kforner commented on August 17, 2024

moved to https://groups.google.com/forum/#!forum/plink2-users

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