Comments (1)
Hi Baike, thanks for the question. In order to be statistically valid the TWAS analysis should use LD from the target/GWAS population. So in your case it sounds like you would need an Asian ancestry LD reference panel. It is still okay to use weights trained in Europeans but does not guarentee that the prediction accuracy will translate, and so you may lose some power when porting across populations.
Best,
Sasha
from fusion_twas.
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from fusion_twas.