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Name: EMBL Huber Group

Type: Organization

Bio: Repository for joint projects by members and ex-members of the Huber group at EMBL. Please see also individuals' pages for further repositories.

Blog: www.huber.embl.de

EMBL Huber Group's Projects

bds3 icon bds3

Biological Data Science

depinfer icon depinfer

DepInfeR is an R package for a computational method that integrates two experimentally accessible input data matrices:\n the drug sensitivity profiles of cancer cell lines or primary tumors ex-vivo (X), and the drug affinities of a set of proteins (Y), to infer a matrix of molecular protein dependencies of the cancers (ß).\n DepInfeR deconvolves the protein inhibition effect on the viability phenotype by using regularized multivariate linear regression. \n It assigns an “dependence coefficient” to each protein and each sample, and therefore could be used to gain causal and accurate understanding of functional consequences of genomic aberrations in a heterogeneous disease, as well as to guide the choice of pharmacological intervention for a specific cancer type, sub-type, or an individual patient.

nparc icon nparc

Nonparametric Analysis of Response Curves from Thermal Proteome Profiling Experiments

ubds3-2024 icon ubds3-2024

Teaching material for the Ukrainian Biological Data Science Summer School 2024

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