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Hi there 👋

I am a Senior Researcher and Lecturer of bioinformatics and computer architecture at SAFARI Research Group, D-ITET, ETH Zürich and a former memeber of D-INFK.

My main research is in bioinformatics, computational genomics, metagenomics, and computer architecture. I am especially excited about building new data structures, algorithms, and architectures that make intelligent computation on population-scale sequencing data a reality. I am also excited about system design, using existing and unconventional (e.g., non-von Neumann) computing paradigms, for bioinformatics and big-data applications. I closely advise and mentor several graduate and undergraduate students (>26 overall) at ETH Zürich, CMU, and Bilkent University. Work with us!

Mohammed Alser's Projects

btllib icon btllib

Bioinformatics Technology Lab common code library

cmash icon cmash

Fast and accurate set similarity estimation via containment min hash

cronjob icon cronjob

⌛ A workaround to permanently store file under the global scratch file system mounted on the Hoffman2 Cluster

gatekeeper icon gatekeeper

GateKeeper: A New Streaming Accelerator Architecture for Fast Pre-Alignment in DNA Short Read Mapping

genome-on-diet-1 icon genome-on-diet-1

Genome-on-Diet is a fast and memory-frugal framework for exemplifying sparsified genomics for read mapping, containment search, and metagenomic profiling. It is much faster & more memory-efficient than minimap2 for Illumina, HiFi, and ONT reads. Described by Alser et al. (preliminary version: https://arxiv.org/abs/2211.08157).

good.software icon good.software

This is the GitHub repository for our recent study "A comprehensive analysis of the usability and archival stability of omics computational tools and resources." Please follow to the repository's wiki for more information and details on how this repository is connected to the paper.

grim icon grim

Source code of the processing-in-memory simulator used in the GRIM-Filter paper published at BMC Genomics in 2018: "GRIM-Filter: Fast Seed Location Filtering in DNA Read Mapping using Processing-in-Memory Technologies" (preliminary version at https://arxiv.org/pdf/1711.01177.pdf)

halcyon icon halcyon

an accurate basecaller exploiting an encoder-decoder model with monotonic attention.

ksw2 icon ksw2

Global alignment and alignment extension

minimap2 icon minimap2

A versatile pairwise aligner for genomic and spliced nucleotide sequences

pairextractor icon pairextractor

It extracts the reference sequence to which a read maps, given the position in the reference sequence

review_technology_dictates_algorithms icon review_technology_dictates_algorithms

This is the GitHub repository for our recent study "Technology dictates algorithms : Recent developments in read alignments." Please follow to the repository's wiki for more information and details on how this repository is connected to the paper.

seq-align icon seq-align

Fast, portable C implementations of Needleman-Wunsch and Smith-Waterman sequence alignment

seqan icon seqan

SeqAn's official repository.

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