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CCB, NKI's Projects

bcm3 icon bcm3

BCM3 - Bayesian Inference for Computational Models

cimpl icon cimpl

Common Insertion Site Mapping Platform implemented as an R package for statistical analysis of retroviral insertional mutagenesis screens.

cnr icon cnr

A method for network reconstruction and quantification from perturbation experiments

cnr-analyses icon cnr-analyses

Notebooks to reproduce the figures from CNR manuscript (Bosdriesz et al., Bioinformatics, 2018)

dids icon dids

R package for the Detection of Imbalanced Differential Signal (DIDS) algorithm.

discover icon discover

DISCOVER co-occurrence and mutual exclusivity analysis for cancer genomics data

imagene-analysis icon imagene-analysis

Radiogenomic analysis of breast cancer by linking MRI phenotypes with tumor gene expression

imfusion icon imfusion

Tool for identifying transposon insertions and their effects from RNA-seq data.

itop icon itop

Infers a topology of relationships between different datasets, such as multi-omics and phenotypic data recorded on the same samples.

itop-rmarkdown icon itop-rmarkdown

An R Markdown file containing code to reproduce all figures from our iTOP publication

kcrbm icon kcrbm

R code for Kernel Convolved Rule Based Mapping

mixedic50 icon mixedic50

A non-linear mixed effects model for estimating compound sensitivity

multitask_vi icon multitask_vi

The Multitask Variable Importance (Multitask VI) is a modified version of the permuted variable importance score for Random Forests. Essentially, for a Random Forest trained simultaneously for multiple response vectors, it allows the inference of variable importance scores per variable and per task.

mvdens icon mvdens

Multivariate probability density approximation R package

percolate icon percolate

Implementation of Percolate, an exponential family JIVE statistical model for multi-view integration

ppbc icon ppbc

Post-partum breast cancer

rubic icon rubic

RUBIC detects recurrent copy number aberrations.

sobolev_alignment icon sobolev_alignment

Sobolev alignment of deep probabilistic models for comparing single cell profiles

tandem icon tandem

A two-stage regression method that can be used when various input data types are correlated, for example gene expression and methylation in drug response prediction. In the first stage it uses the upstream features (such as methylation) to predict the response variable (such as drug response), and in the second stage it uses the downstream features (such as gene expression) to predict the residuals of the first stage. In our manuscript (Aben et al., 2016), we show that using TANDEM prevents the model from being dominated by gene expression and that the features selected by TANDEM are more interpretable.

transact icon transact

Python implementation of TRANSACT, a tool to transfer non-linear predictors of drug response from model systems to tumors.

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