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nellac77 avatar nellac77 commented on June 9, 2024 1

Seems like I am a few years late here, but as the author of this paper I can tell you that I did make a mistake in that equation and it is supposed to be C^2.

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lungd avatar lungd commented on June 9, 2024

Seems like you are right.
With 2C:

wrongequ

With CĀ² the output of the gating params look more like what we can see in the paper but there is a difference in the spike width and the number of spikes:

out

out2

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pgleeson avatar pgleeson commented on June 9, 2024

There is also the issue that the equation even with C^2 is not giving the correct form for the inactivation as shown in Fig 3:

selection_275

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VahidGh avatar VahidGh commented on June 9, 2024

This is the general form of Gaussian expression:

image

Maybe 2C^2 is what the author mean!

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pgleeson avatar pgleeson commented on June 9, 2024

I've changed channel to use 2C^2 in the channel as @VahidGh suggested, and along with a few other changes, the model is looking close to the figures:

selection_297

There are now 2 versions of the model
LEMS_Figure7_ScaledCell.xml which uses a cell with no segments and tries to keep as close to the paper's units (e.g. 1uA input current)
and
LEMS_Figure7.xml
which has a cell with dimensions close to the c elegans muscle, which should be better for use in c302 etc.

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pgleeson avatar pgleeson commented on June 9, 2024

It's never too late! Thanks for the clarification.

By the way @nellac77, do you know of any follow up work that used this model or similar?

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