Comments (4)
Common clinical trials match criteria. The component of the list may vary from trial to trial and not an exhaustive list. I'm happy to chat further.
Inclusion criteria
- Age 18 or over
- Eastern Cooperative Oncology Group (ECOG) status 0-2
- Diagnosis of prostate cancer
- Prostate cancer on biopsy from a mpMRI defined lesion
- Normal full blood count and normal renal and liver function tests
- Any prior systemic therapy for prostate cancer( e.g. surgery, chemo, radiation)
- Co-morbidities( past medical problems)
-Stage of the cancer
-Gleason grade on biopsy
Exclusion criteria
- To unwell, ECOG 3-4
- Lack of mental capacity
-History of HIV or hepatitis B or C
-History of auto-immune disease
-Prior treatment with immunotherapy
-Previous history of other types of cancer
-Active invasive malignancy in the previous 2 years excluding non-melanoma skin cancer.
-Significant cardiovascular disease, myocardial infarction within 3 months prior to enrolment,
-History of QT prolongation
-Men unable to have MRI scan, or in whom artefact would significantly reduce quality of MR
-Contraindications to biopsy
-Unable to communicate in English
from curenetics.
sorry I mixed up my bullet point signs.
from curenetics.
Hi @sesola - sorry I think we still need this to be made much simpler for us (at least me) to understand!
For each of these - what words could we expect to see on the medical record, which Jon will pull out AND what sort of relevant keywords would we look for in the list of clinical trials?
For example, diagnosis of prostate cancer - what are the full list of terms that might be provided?
I've provided a spreadsheet template that might be useful for you and maybe with help from @jbrough to fill in? https://docs.google.com/spreadsheets/d/1vwfUVFS4Rov0nnbV-o2ew6kcAnMzbXXmI3xgfGluEME/edit?usp=sharing
Basically, we have no expertise in this domain, so if we are going to have a chance to match on anything other than age, gender, type of cancer, we need a super clear list for each potential criteria, what would be the keywords we could pull out of a medical record that might be listed in a clinical trial which we can 100% assume will mean the patient either meets or doesn't meet that particular criteria.
Hope that makes sense! Let me know if you'd like to chat through
from curenetics.
This has been agreed to be ECOG status, gleason score and disease outside / within prostate
so closing this issue now
from curenetics.
Related Issues (20)
- Warning modal not working HOT 2
- Scroll to top HOT 2
- Link up the actual custom Loading component
- Add spacing between Export Results and the icon
- Put filename at top of exports
- Clinical Trials design issues HOT 1
- Warning modal doesnโt appear when you click any button that might take you away from the results
- Header on mobile looks odd
- Location always shows 5 miles HOT 2
- Limit nearest locations to 5
- Add postcode input to enter details manually
- Bug fixing HOT 4
- More sorting options for matched trials HOT 1
- To remove old version from online searches
- New bugs for fixing HOT 4
- Validation on patient's age
- Remove irrelevant eligible criteria for cancer types other than prostate
- Loading page is rendering text outside of screen
- Spacing issues on clinical results
- Show 'N/A' rather than 'No data' on clinical results
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from curenetics.