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zhanglabtools's Projects

adc icon adc

source code for ADC

bmd-mog icon bmd-mog

The code file for paper BMD-MoG. main file: BMD_MoG.m

came icon came

Cell-type Assignment and Module Extraction based on a heterogeneous graph neural network.

circlet icon circlet

CIRCLET, a powerful tool for accurate reconstruction of circular trajectory with high resolution by considering multi-scale features of chromosomal architectures of single cells. Further division of the reconstructed trajectory helps to accurately characterize the dynamics of chromosomal structures and uncover important regulatory genes along cell-cycle progression, providing a novel framework for discovering regulatory regions even cancer markers at single-cell resolution.

csre icon csre

The code of article "Large-scale determination and characterization of cell type-specific regulatory elements in the human genome"

dbmd icon dbmd

Distributed Matrix Decomposition for Big Data Mining and Clustering

dnadataaugmentation icon dnadataaugmentation

Source code for paper 'Simple tricks of convolutional neural network architectures improve DNA–protein binding prediction'. In addition, some reusable code is also sort out for further use.

gkm-dnn icon gkm-dnn

R and Scala code for calculating gapper k-mer frequency vector

hicsrkit icon hicsrkit

A package used to enhance Hi-C maps with deep learning

mactop icon mactop

deciphering chromatin domain, domain community and chromunity for 3D genome maps

mn-pca icon mn-pca

Matrix normal PCA for interpretable dimension reduction and graphical noise modeling

mstd icon mstd

MSTD is a generic and efficient method to identify multi-scale topological domains (MSTD) from symmetric Hi-C and other high resolution asymmetric promoter capture Hi-C datasets.

schi-csim icon schi-csim

scHi-CSim, a simulator for generating single-cell Hi-C data.

stagate icon stagate

Adaptive Graph Attention Auto-encoder for Spatial Domain Identification of Spatial Transcriptomics

stagewisenn icon stagewisenn

Constructing developmental tree from scRNA-seq data

staligner icon staligner

STAligner: Integrating spatial transcriptomics data across different conditions, technologies, and developmental stages

stamarker icon stamarker

STAMarker: Identify Spatial Domain-specific Variable Genes via Ensemble Graph Attention Autoencoders

twae icon twae

A non-adversarial generative autoencoder with divide-and-conquer strategy

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