Comments (1)
trvrb
commented on July 24, 2024
1
TreeTime (and other programs which compute time trees such as BEAST) don't work well for situations where there is substantially evolutionary time. The presence of repeated mutations confused the normal clock estimates. It's possible to infer a date to the common ancestor of nCoV and RaTG13 (see here http://virological.org/t/divergence-of-ncov-2019-to-closest-non-human-relative/388), but I wouldn't go much too much further back than this.
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