NCG is a single-cell potency model to predict single-cell differentiation and discriminate pluripotent and non-pluripotent cells under R version 3.6.0.
NCG was proposed by following steps:
(1) Computation of Edge Clustering Coefficient (ECC) based on PPI network,
(2) Computation of gene-to-gene functional similarities using GO terms,
(3) Assignment of gene-to-gene functional similarities as weights to ECC,
(4) Combination of weighted ECC with scRNA-Seq data.