co1yzha/crescenddi

CRESCENDDI: A Clinically-relevant REference Set CENtered around Drug-Drug Interactions

This repository contains code used for generating CRESCENDDI (https://doi.org/10.6084/m9.figshare.c.5481408), a reference set aimed to facilitate research in postmarketing surveillance related to drug-drug interactions. It includes scripts for data extraction, concept normalisation, generation of positive and negative controls, and application of signal detection algorithms to screen spontaneous reporting system databases.

See the documentation folder for more information.

Kontsioti, E., Maskell, S., Dutta, B. et al. A reference set of clinically relevant adverse drug-drug interactions. Sci Data 9, 72 (2022). https://doi.org/10.1038/s41597-022-01159-y