emily23king/protein-degradation

Year	Month	First author	Title / Link	Journal	Computational?
2021	11	Lv	Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity	Nature Communications	X
2021	10	Wang	UbiBrowser 2.0: a comprehensive resource for proteome-wide known and predicted ubiquitin ligase/deubiquitinase–substrate interactions in eukaryotic species	Nucleic Acids Research
2021	10	Imaide	Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity	Nature Chemical Biology
2021	10	Zhang	Covalently Engineered Nanobody Chimeras for Targeted Membrane Protein Degradation	JACS	*
2021	09	Zhang	Machine learning modeling of protein-intrinsic features predicts tractability of targeted protein degradation	bioRxiv	*
2021	09	Belcher	Ligandability of E3 Ligases for Targeted Protein Degradation Applications	Biochemistry
2021	08	Hughes	The rise and rise of protein degradation: Opportunities and challenges ahead	Drug Discovery Today
2021	08	Shao	Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG	Advanced Science
2021	07	Schneider	The PROTACtable genome	Nature Reviews Drug Discovery	*
2021	07	Rodriguez-Rivera	Unifying Catalysis Framework to Dissect Proteasomal Degradation Paradigms	ACS Central Science
2021	07	Douglas	Ternary Kinetic Models for Rational Design of Molecular Glues	chemRxiv	*
2021	06	Reynders	Optical control of targeted protein degradation	Cell Chemical Biology
2021	06	Dale	Advancing targeted protein degradation for cancer therapy	Nature Reviews Cancer
2021	06	Liu	TF-PROTACs Enable Targeted Degradation of Transcription Factors	Journal of the American Chemical Society
2021	05	Kannt	Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation	Cell Chemical Biology
2021	05	Nishiguchi	Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators	Journal of Medicinal Chemistry
2021	05	Cecchini	From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation	Frontiers in Chemistry
2021	04	Jetvic	An E3 ligase guide to the galaxy of small-molecule-induced protein degradation	Cell Chemical Biology
2021	04	Henning	Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications	bioRxiv
2021	04	Henneberg	Decoding the messaging of the ubiquitin system using chemical and protein probes	Cell Chemical Biology
2021	04	Scholes	Identification and selectivity profiling of small-molecule degraders via multi-omics approaches	Cell Chemical Biology
2021	04	Farnaby	Transforming targeted cancer therapy with PROTACs: A forward-looking perspective	Current Opinion in Pharmacology
2021	03	Kiely-Collins	The role of reversible and irreversible covalent chemistry in targeted protein degradation	Cell Chemical Biology
2021	03	Zhang	DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras	JACS
2021	03	Castaldi	Advances in Protein Degradation	SLAS Discovery
2021	03	Ahn	Degradation from the outside in: targeting extracellular and membrane proteins for degradation through the endolysosomal pathway	Cell Chemical Biology
2021	03	Ege	Phenotypic screening with target identification and validation in the discovery and development of E3 ligase modulators	Cell Chemical Biology
2021	03	Bond	Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation	RSC Chemical Biology
2021	03	Ahn	LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation	Nature Chemical Biology
2021	03	Pei	Targeting Lysosomal Degradation Pathways: New Strategies and Techniques for Drug Discovery	Journal of Medicinal Chemistry
2021	03	Jiang	Discovery and resistance mechanism of a selective CDK12 degrader	Nature Chemical Biology
2021	03	Hundley	A comprehensive phenotypic CRISPR-Cas9 screen of the ubiquitin pathway uncovers roles of ubiquitin ligases in mitosis	Molecular Cell
2021	03	Mullard	Targeted protein degraders crowd into the clinic	Nature Reviews Drug Discovery
2021	03	Spradlin	Reimagining Druggability Using Chemoproteomic Platforms	Accounts of Chemical Research
2021	03	Shao	Destruction of DNA-binding proteins by programmable O’PROTAC: Oligonucleotide-based PROTAC	bioRxiv
2021	03	Zheng	Novel PROTACs for degradation of SHP2 protein	Bioorganic Chemistry
2021	03	Jaeger	Fast-acting chemical tools to delineate causality in transcriptional control	Molecular Cell
2021	03	Mohler	An Overview of Next-Generation Androgen Receptor-Targeted Therapeutics in Development for the Treatment of Prostate Cancer	International Journal of Molecular Sciences
2021	03	Wang	Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy	Nature Chemical Biology
2021	03	Kim	Avoid the trap: targeting PARP1 beyond human malignancy	Cell Chemical Biology
2021	03	Jan	Cancer therapies based on targeted protein degradation — lessons learned with lenalidomide	Nature Reviews Clinical Oncology
2021	03	Zhang	Ubiquitination of Nonhistone Proteins in Cancer Development and Treatment	Frontiers in Oncology
2021	03	Kastl	Small-Molecule Degraders beyond PROTACs—Challenges and Opportunities	SLAS Discovery
2021	02	Peter	A novel, universally active C-terminal protein degradation signal generated by alternative splicing	Journal of Molecular Biology
2021	02	Schreiber	The Rise of Molecular Glues	Cell
2021	02	Zhang	SPIN4 Is a Principal Endogenous Substrate of the E3 Ubiquitin Ligase DCAF16	Biochemistry
2021	02	Kolb	Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells	Nature Communications
2021	02	Bai	Rationalizing PROTAC-Mediated Ternary Complex Formation Using Rosetta	Journal of Chemical Information and Modeling	X
2021	02	Liu	Design and Synthesis of EZH2-Based PROTACs to Degrade the Complex for Targeting the Noncatalytic Activity of EZH2	Journal of Medicinal Chemistry
2021	02	Dragovich	Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties	Journal of Medicinal Chemistry
2021	02	Dragovich	Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy	Journal of Medicinal Chemistry
2021	02	Tokheim	Systematic characterization of mutations altering protein degradation in human cancers	Molecular Cell	X
2021	02	Alabi	Mutant-selective degradation by BRAF-targeting PROTACs	Nature Communications
2021	02	Kaiho-Soma	TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains	Molecular Cell
2021	02	Powell	Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library	ACS Chemical Biology
2021	02	Cao	Recent insight into the role of RING-finger E3 ligases in glioma	Biochemical Society Transactions
2021	02	Horn-Ghetko	Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly	Nature
2021	02	Koduri	Targeting oncoproteins with a positive selection assay for protein degraders	Science Advances
2021	02	Gabizon	The rise of covalent proteolysis targeting chimeras	Current Opinion in Chemical Biology
2021	01	Ermondi	PROTACs and Building Blocks: The 2D Chemical Space in Very Early Drug Discovery	Molecules	X
2021	01	Maiwald	Sweet and Blind Spots in E3 Ligase Ligand Space Revealed by a Thermophoresis-Based Assay	ACS Medicinal Chemistry Letters
2021	01	Kessler	DUB esterase activity further decodes ubiquitin’s enigma	PNAS
2021	01	De Cesare	Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases	PNAS
2021	01	Yeh	The C‐degron pathway eliminates mislocalized proteins and products of deubiquitinating enzymes	EMBO Journal
2021	01	Serapian	Exploiting the folding and degradation machineries to target undruggable proteins: What can the computational approach tell us?	ChemMedChem	X
2021	01	Luo	Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function	Cell Chemical Biology
2021	01	Jan	Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide	Science Translational Medicine
2021	01	Shirasaki	Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins	Cell Reports
2021	01	Benowitz	The therapeutic potential of PROTACs	Expert Opinion on Therapeutic Patents
2021	01	Yan	Discovery of a PROTAC targeting ALK with in vivo activity	European Journal of Medicinal Chemistry
2021	01	Cotton	Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1	Journal of the American Chemical Society
2021	01	Banchenko	Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses	bioRxiv
2021	01	Zeng	Proteolysis targeting chimera (PROTAC) in drug discovery paradigm: Recent progress and future challenges	European Journal of Medicinal Chemistry
2021	01	Martín-Acosta	PROTACs to address the challenges facing small molecule inhibitors	European Journal of Medicinal Chemistry
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2020	12	Atilaw	Solution Conformations Shed Light on PROTAC Cell Permeability	ACS Medicinal Chemistry Letters
2020	12	Caine	Targeted Protein Degradation Phenotypic Studies Using HaloTag CRISPR/Cas9 Endogenous Tagging Coupled with HaloPROTAC3	Current Protocols in Pharmacology
2020	12	Leissing	Structure driven compound optimization in targeted protein degradation	Drug Discovery Today
2020	12	Tong	Bardoxolone conjugation enables targeted protein degradation of BRD4	Scientific Reports
2020	12	Liu	A Proteomic Platform to Identify Off-Target Proteins Associated with Therapeutic Modalities that Induce Protein Degradation or Gene Silencing	bioRxiv
2020	12	Donovan	Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development	Cell
2020	11	Chatterjee	Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions	Communications Biology
2020	11	Matyskiela	Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons	ACS Chemical Biology
2020	11	Schiemer	Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes	Nature Chemical Biology
2020	11	Adhikari	PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase	Nature Chemical Biology
2020	10	Nabet	Charting a New Path Towards Degrading Every Protein	ChemBioChem
2020	10	Jiang	PROTACs suppression of GSK-3β, a crucial kinase in neurodegenerative diseases	European Journal of Medicinal Chemistry
2020	10	Ghidini	RNA‐PROTACs – degraders of RNA‐binding proteins	Angewandte Chemie International Edition
2020	10	Bartlett	A kinetic proofreading model for bispecific protein degraders	Journal of Pharmacokinetics and Pharmacodynamics	X
2020	10	Samarasinghe	Targeted Degradation of Transcription Factors by TRAFTACs: Transcription Factor Targeting Chimeras	bioRxiv
2020	10	Weinmann and Crews	Protein Degradation with New Chemical Modalities: Successful Strategies in Drug Discovery and Chemical Biology	Ebook: Royal Society of Chemistry	X (some)
2020	10	Lee	Targeted Degradation of Transcription Coactivator SRC‐1 through the N‐Degron Pathway	Angewandte Chemie International Edition
2020	10	Goracci	Understanding the Metabolism of Proteolysis Targeting Chimeras (PROTACs): The Next Step toward Pharmaceutical Applications	Journal of Medicinal Chemistry
2020	10	Miyamae	A Method for Conditional Regulation of Protein Stability in Native or Near-Native Form	Cell Chemical Biology
2020	10	Weng	PROTAC-DB: an online database of PROTACs	Nucleic Acids Research	X
2020	10	Yang	Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases	Nature Communications
2020	10	Bushman	Proteomics-Based Identification of DUB Substrates Using Selective Inhibitors	Cell Chemical Biology
2020	09	Furihata	Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide	Nature Communications
2020	09	Qin	The therapeutic effect of the BRD4-degrading PROTAC A1874 in human colon cancer cells	Cell Death and Disease
2020	09	Zaidman	PRosettaC: Rosetta based modeling of PROTAC mediated ternary complexes	Journal of Chemical Information and Modeling	X
2020	09	Drummond	Improved Accuracy for Modeling PROTAC-Mediated Ternary Complex Formation and Targeted Protein Degradation via New In Silico Methodologies	Journal of Chemical Information and Modeling	X
2020	09	Cao	Induced protein degradation of histone deacetylases 3 (HDAC3) by proteolysis targeting chimera (PROTAC)	European Journal of Medicinal Chemistry
2020	09	Simpson	Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System	Cell Chemical Biology
2020	08	Nalawansha	PROTACs: An Emerging Therapeutic Modality in Precision Medicine	Cell Chemical Biology
2020	08	Liang	Design and pharmaceutical applications of proteolysis-targeting chimeric molecules	Biochemical Pharmacology
2020	08	Cipriano	Targeting epigenetic reader domains by chemical biology	Current Opinion in Chemical Biology
2020	08	Mayor-Ruiz	Rational discovery of molecular glue degraders via scalable chemical profiling	Nature Chemical Biology
2020	08	Han	A suite of mathematical solutions to describe ternary complex formation and their application to targeted protein degradation by heterobifunctional ligands	Journal of Biological Chemistry	X
2020	08	Mabbitt	Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity	Nature Chemical Biology
2020	07	Timms	Tying up loose ends: the N-degron and C-degron pathways of protein degradation	Biochemical Society Transactions
2020	07	Beveridge	Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy	ACS Central Science
2020	07	Chung	Structural Insights into PROTAC-Mediated Degradation of Bcl-xL	ACS Chemical Biology
2020	07	Ruprecht	A mass spectrometry-based proteome map of drug action in lung cancer cell lines	Nature Chemical Biology
2020	06	Hanzl	Targeted protein degradation: current and future challenges	Current Opinion in Chemical Biology
2020	05	Luh	Prey for the Proteasome: Targeted Protein Degradation – A Medicinal Chemist´s Perspective	Angewandte Chemie International Edition
2020	03	Imrie	Deep Generative Models for 3D Linker Design	Journal of Chemical Information and Modeling	X
2020	03	Wu	Small molecules that target the ubiquitin system	Biochemical Society Transactions
2020	02	Deshaies	Multispecific drugs herald a new era of biopharmaceutical innovation	Nature
2020	02	Wang	Degradation of proteins by PROTACs and other strategies	Acta Pharmaceutica Sinica B
2020	01	Moreau	Proteolysis‐targeting chimeras in drug development: A safety perspective	British Journal of Pharmacology
2020	01	Gong	Targeting Cullin-RING Ubiquitin Ligases and the Applications in PROTACs	Advances in Experimental Medicine and Biology
2020	01	Yang	The Evolving Druggability and Developability Space: Chemically Modified New Modalities and Emerging Small Molecules	The AAPS Journal
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2019	12	Sun	Protacs: Great opportunities for academia and industry	Signal Transduction and Targeted Therapy
2019	10	Schapira	Targeted protein degradation: expanding the toolbox	Current Opinion in Chemical Biology
2019	10	Maple	Developing degraders: principles and perspectives on design and chemical space	MedChemComm
2019	09	Chamberlain	Development of targeted protein degradation therapeutics	Nature Chemical Biology
2019	08	Maniaci	Bifunctional chemical probes inducing protein–protein interactions	Current Opinion in Chemical Biology
2019	07	Spradlin	Harnessing the anti-cancer natural product nimbolide for targeted protein degradation	Nature Chemical Biology
2019	06	Ella	The Hunt for Degrons of the 26S Proteasome	Biomolecules
2019	04	Paiva	Targeted protein degradation: elements of PROTAC design	Current Opinion in Chemical Biology
2019	04	Roth	Advances in targeted degradation of endogenous proteins	Cellular and Molecular Life Sciences
2019	03	Simonetta	Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction	Nature Communications	X
2019	02	Drummond	In Silico Modeling of PROTAC-Mediated Ternary Complexes: Validation and Application	Journal of Chemical Information and Modeling	X
2019	01	Buhimschi	Evolving Rules for Protein Degradation? Insights from the Zinc Finger Degrome	Biochemistry
2019	01	Liu	UbiHub: a data hub for the explorers of ubiquitination pathways	Bioinformatics	X
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2018	09	Clift	Acute and rapid degradation of endogenous proteins by Trim-Away	Nature Protocols	X
2018	08	Lucas	Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase	Journal of Medicinal Chemistry	X
2018	06	Fisher	Targeted protein degradation and the enzymology of degraders	Current Opinion in Chemical Biology
2018	03	Ge	Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types	Cell Reports	X
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2017	05	Gadd	Structural basis of PROTAC cooperative recognition for selective protein degradation	Nature Chemical Biology
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2016	07	Medvar	Comprehensive database of human E3 ubiquitin ligases: application to aquaporin-2 regulation	Physiological genomics