nature-communications-junctions's Introduction

Nature-Communications-Junctions

Code from McEvoy et al. (2022) Nature Communications

This repository contains the following files:

A MATLAB (last tested on ver 2020b) file to simulate remodeling of a tri-cellular junction: "Nat_comms_vertex.m"
A COMSOL Multiphysics (last tested on ver5.4a) finite element model to support supplementary analytical model of tri-cell junction stress: "Vertex_FE.mph"

All files and software were tested in Windows 10. ** Code commented within "Nat_comms_vertex.m" for detailed explanation of analysis.

Matlab code demo:

Install MATLAB (https://www.mathworks.com/products/matlab.html). The installation usually takes approximately 1 hour.
Open "Nat_comms_vertex.m" and click "Run".

New windows will then open with the simulated results

Note: This file is configured to reproduce simulated junction dynamics at cell vertices [Figure 4]. All other results may be reproduced my modifying parameters, as outlined in the manuscript.

COMSOL simulation demo:

Install COMSOL Multiphysics (https://www.comsol.com/). The installation usually takes approximately 1.5 hours.
Open "Vertex_FE.mph".
Navigate to "Settings" [middle panel] and click on "Compute".

Model may be used to obtain FEM reults within Figure S2.

To ensure accurate reproduction of results we recommend you reopen the unedited files provided before modifying parameters and settings.
The demos may take 10 minutes to run depending on the machine.

For any questions regarding these files, please contact Eoin McEvoy ([email protected]).

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