greenelab / czi-rfa Goto Github PK
View Code? Open in Web Editor NEWApplication to "Collaborative Computational Tools for the Human Cell Atlas" https://chanzuckerberg.com/initiatives/rfa
License: Other
Application to "Collaborative Computational Tools for the Human Cell Atlas" https://chanzuckerberg.com/initiatives/rfa
License: Other
@lanagarmire mentioned to me that she will be putting in an application for a visualization & workflow system. I will mention this in our collaborative network too.
Copied from the RFA
The goals of this RFA include, but are not limited to:
Single-cell RNA-seq data is sparse/zero-inflated. There are several works [1-3] showing advantages of modeling zero-inflated distances between cells over L-1/L-2 distances.
For the VAE in aim 1, I expect that using zero inflated loss rather than euclidean reconstruction loss would work significantly better.
[1] https://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0805-z
[2] https://arxiv.org/abs/1610.05857
[3] https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1188-0
We will need more detail from Arjun to provide an example. I think you should make a hypothetical example of the latent space arithmetic experimental design. What about doing it as single cell data + bulk perturbation & comparing to single cell + perturbation? That seems like the cleanest design to test your hypothesis.
We will use this issue to discuss the nature of the data and experimental design to test the hypothesis:
that the latent space will preserve vector arithmetic operations between state transitions within benchmark perturbation expression datasets.
The issue can be closed once the experimental design is updated in aim 3.
A declarative, efficient, and flexible JavaScript library for building user interfaces.
๐ Vue.js is a progressive, incrementally-adoptable JavaScript framework for building UI on the web.
TypeScript is a superset of JavaScript that compiles to clean JavaScript output.
An Open Source Machine Learning Framework for Everyone
The Web framework for perfectionists with deadlines.
A PHP framework for web artisans
Bring data to life with SVG, Canvas and HTML. ๐๐๐
JavaScript (JS) is a lightweight interpreted programming language with first-class functions.
Some thing interesting about web. New door for the world.
A server is a program made to process requests and deliver data to clients.
Machine learning is a way of modeling and interpreting data that allows a piece of software to respond intelligently.
Some thing interesting about visualization, use data art
Some thing interesting about game, make everyone happy.
We are working to build community through open source technology. NB: members must have two-factor auth.
Open source projects and samples from Microsoft.
Google โค๏ธ Open Source for everyone.
Alibaba Open Source for everyone
Data-Driven Documents codes.
China tencent open source team.