jlubo/arbor_2n1s

Arbor simulation of the induction of early- and late-phase plasticity at a single synapse

Arbor simulation of the induction of early- and late-phase plasticity at a single synapse

This code simulates a current-based, plastic synapse that connects two leaky integrate-and-fire neurons. The synapse model reproduces the outcome of established plasticity-inducing protocols by featuring early-phase plasticity based on calcium dynamics and late-phase plasticity based on synaptic tagging and capture.

It has been tested with Arbor version 0.8.1.

The following protocols are provided and can be run by the bash scripts of the same name:

• "run_arbor_basic_early": demonstrates the simulation of basic calcium and early-phase plasticity dynamics. The presynaptic neuron spikes at predefined times and thereby stimulates the postsynaptic site and induces plasticity.
• "run_arbor_classical_protocols": reproduces classical induction protocols for early- and late-phase long-term potentiation and depression. The presynaptic neuron spikes in a Poissonian manner according to one of the protocols {STET, WTET, SLFS, WLFS}, thereby stimulating the postsynaptic site and inducing plasticity.

The underlying synapse and neuron model has been described in detail in Luboeinski & Tetzlaff, 2021.

Basic early-phase dynamics

Noise in plasticity generated from seed 0:

No noise in plasticity:

Classical plasticity-inducing protocols

For details see, for example, Sajikumar et al., 2005 or Luboeinski & Tetzlaff, 2021.

STET:

WTET:

SLFS:

WLFS: