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Profiling results about kevlar HOT 2 OPEN

kevlar-dev avatar kevlar-dev commented on September 8, 2024
Profiling results

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standage avatar standage commented on September 8, 2024 1

Perhaps. I'd need to create a consume_string_banding function, but probably want to do this anyway,

That said, based on my most recent discussion with Fereydoun, we're probably going to settle for discarding reads with non-ACGT. This represents a small portion of data, and if any of our variant calls are coming only from these potentially problematic reads then that's a cause for skepticism anyway. And if I understand correctly, the Cython-based read pre-processing is moving in this direction anyway, so this should make our life much easier!

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betatim avatar betatim commented on September 8, 2024

Can you do your preprocessing on a per read basis or is it per kmer? Wondering if you could speed things along by passing a read to consume_string instead of calling add for each kmer. It might reduce the (notoriously large) function call overhead of python and maybe we make some gains by having the loop in c++?

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