manasdhanuka/bf591-r-final-project

Final semester project for the course; R for Biological Science

bf591-R-final-project

Final semester project for the course; R for Biological Science

📄 app.R

• Script for a interactive R Shiny suite made to vizualize and analyze the data produced by Labadorf et al. in the 2015 study mRNA-Seq Expression profiling of human post-mortem BA9 brain tissue for Huntington's Disease and neurologically normal individuals.

• The app performs

  • Summary of the data

  

  • Counts Matrix Analysis

  

  • Differential Expression Analysis

  

  • GSEA (Geneset Enrichment Analysis)

  

📁 Data

• Directory containing all the supporting data files

Contributor

Manas Dhanuka

References

• Labadorf A, Hoss AG, Lagomarsino V, Latourelle JC, Hadzi TC, Bregu J, MacDonald ME, Gusella JF, Chen JF, Akbarian S, Weng Z, Myers RH. RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression. PLoS One. 2015 Dec 4;10(12):e0143563. doi: 10.1371/journal.pone.0143563. Erratum in: PLoS One. 2016;11(7):e0160295. PMID: 26636579; PMCID: PMC4670106.