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bobGSmith avatar bobGSmith commented on June 1, 2024 1

He used a sort of keyword search for that one if I remember correctly. I could get the disease descriptions from the HPO API and add that to the searchable info maybe? Or I could do it by branch, e.g. what percentage of significant immune cell enrichments are from the "Abnormality of the immune system" branch?
@NathanSkene @bschilder

from rare_disease_celltyping.

bobGSmith avatar bobGSmith commented on June 1, 2024 1

@bschilder Yeah ill stick with branch descendants rather than keyword search stuff then. They are all just different options for subsetting the data but using the branches is a lot easier to work with

from rare_disease_celltyping.

bobGSmith avatar bobGSmith commented on June 1, 2024

I have been experimenting with some stuff. I'm just defining the enrichments based on what main HPO branch they come from, but could try a keyword thing like Jai. Rather than picking an individual cell type, I used all immune system-related cells or all cardiovascular system-related cells. Then counted the number of significant enrichments from each branch for that group of cells.

I think this could be quite a cool way to show more than one class of cell in a single figure:
immune_cardio_radial
Rather than just targeting those branches i picked out, i could just include all main HPO branches. Also could try make a function for it so can try any group of cells and any sub-branch i guess.

I started looking at bar and pie charts too (for immune only)
immune_expected_bar

immune_expected_pie

@NathanSkene @bschilder

from rare_disease_celltyping.

bschilder avatar bschilder commented on June 1, 2024

@ovrhuman i really like that spider/radial plot! i think this is a great way to summarise these multi-dimensional findings in an intuitive way.

Rather than just targeting those branches i picked out, i could just include all main HPO branches. Also could try make a function for it so can try any group of cells and any sub-branch i guess.

I was thinking the same thing, users could choose which terms (at any level) they want to populate the "spokes" with. Could even be specific diseases.

He used a sort of keyword search for that one if I remember correctly. I could get the disease descriptions from the HPO API and add that to the searchable info maybe? Or I could do it by branch, e.g. what percentage of significant immune cell enrichments are from the "Abnormality of the immune system" branch?

Yes, i think breaking it down by branch makes sense to me. I'll leave it up to you to determine the exact level of resolution.

from rare_disease_celltyping.

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