Comments (4)
He used a sort of keyword search for that one if I remember correctly. I could get the disease descriptions from the HPO API and add that to the searchable info maybe? Or I could do it by branch, e.g. what percentage of significant immune cell enrichments are from the "Abnormality of the immune system" branch?
@NathanSkene @bschilder
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@bschilder Yeah ill stick with branch descendants rather than keyword search stuff then. They are all just different options for subsetting the data but using the branches is a lot easier to work with
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I have been experimenting with some stuff. I'm just defining the enrichments based on what main HPO branch they come from, but could try a keyword thing like Jai. Rather than picking an individual cell type, I used all immune system-related cells or all cardiovascular system-related cells. Then counted the number of significant enrichments from each branch for that group of cells.
I think this could be quite a cool way to show more than one class of cell in a single figure:
Rather than just targeting those branches i picked out, i could just include all main HPO branches. Also could try make a function for it so can try any group of cells and any sub-branch i guess.
I started looking at bar and pie charts too (for immune only)
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@ovrhuman i really like that spider/radial plot! i think this is a great way to summarise these multi-dimensional findings in an intuitive way.
Rather than just targeting those branches i picked out, i could just include all main HPO branches. Also could try make a function for it so can try any group of cells and any sub-branch i guess.
I was thinking the same thing, users could choose which terms (at any level) they want to populate the "spokes" with. Could even be specific diseases.
He used a sort of keyword search for that one if I remember correctly. I could get the disease descriptions from the HPO API and add that to the searchable info maybe? Or I could do it by branch, e.g. what percentage of significant immune cell enrichments are from the "Abnormality of the immune system" branch?
Yes, i think breaking it down by branch makes sense to me. I'll leave it up to you to determine the exact level of resolution.
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Related Issues (20)
- Recreate entire study in one Rmarkdown HOT 2
- Describe Human Cell Landscape CTD levels HOT 2
- Assess pLI in HPO genes HOT 6
- `phenomix`: Exploring more efficient methods for celltype enrichment HOT 5
- Identify variant-level mechanisms of each rare disease HOT 3
- Update website with the results from the new scRNA-seq datasets HOT 1
- Assess our results against known phenotype-celltype links HOT 4
- Regenerate manuscript figures with new results HOT 2
- Rewrite manuscript HOT 2
- Remake equations with color coding HOT 1
- Adjust congenital onset figure HOT 1
- Remove diagnosis/prognosis figures
- Redo Monarch recall stats HOT 1
- Create static versions of network plots
- Adjust ontology levels figure HOT 5
- Rework target prioritisation figure HOT 1
- Assess distribution of congenital phenotypes HOT 7
- Target prioritisation pipeline figure HOT 1
- Move AD/PD networks to supplementary materials HOT 1
- Include animal model availability in target prioritisation pipeline
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