open-systems-pharmacology/gemfibrozil-repaglinide-ddi

Modeling of published clinical gemfibrozil-repaglinide-DDI studies for model evaluation

Gemfibrozil-Repaglinide-DDI

Modeling of published clinical gemfibrozil-repaglinide-DDI studies for model evaluation

Repository files

Within this repository, we distribute a PK-Sim project file containing simulations of all published clinical studies used to evaluate the predictive performance of our models regarding the gemfibrozil-repaglinide-DDI, including the respective observed data digitized from literature reports. For further details and documentation please refer to [1].

Version information

PK-Sim Version 7.3.0

Code of conduct

Everyone interacting in the Open Systems Pharmacology community (codebases, issue trackers, chat rooms, mailing lists etc...) is expected to follow the Open Systems Pharmacology code of conduct.

Contribution

We encourage contribution to the Open Systems Pharmacology community. Before getting started please read the contribution guidelines. If you are contributing code, please be familiar with the coding standard.

License

The model code is distributed under the GPLv2 License.

Reference

[1] Türk D, Hanke N, Wolf S, Frechen S, Eissing T, Wendl T, Schwab M, Lehr T. Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug–Drug–Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole. Clinical Pharmacokinetics 2019, https://link.springer.com/article/10.1007/s40262-019-00777-x