opensourcebrain/l5bpyrcellhayetal2011

Layer 5b Pyramidal cell - Hay et al. 2011

Layer 5b Pyramidal cell, Hay et al. 2011

Layer 5b Pyramidal cell constrained by experimental data on perisomatic firing properties as well as dendritic activity during backpropagation of the action potential.

From: Models of Neocortical Layer 5b Pyramidal Cells Capturing a Wide Range of Dendritic and Perisomatic Active Properties, Etay Hay, Sean Hill, Felix Schürmann, Henry Markram and Idan Segev, PLoS Comp Biol 2011.

For more details, see http://www.opensourcebrain.org/projects/l5bpyrcellhayetal2011

Reusing this model

The code in this repository is provided under the terms of the software license included with it. If you use this model in your research, we respectfully ask you to cite the references outlined in the CITATION file.

l5bpyrcellhayetal2011's Issues

Implement NeuroML 2 version of calcium pool mechanism

Need to make custom NML2 implementation which behaves identically to mod file impl:
https://github.com/OpenSourceBrain/L5bPyrCellHayEtAl2011/blob/master/neuroConstruct/cellMechanisms/CaDynamics_E2_init_mod/CaDynamics_E2.mod

Implement NetPyNE bits to run Hay model

Bits in NetPyNE: https://github.com/suny-downstate-medical-center/netpyne/blob/e10aa9187afca9be5d54c11c7ca21abaa8382de7/netpyne/conversion/neuromlFormat.py#L1299

Other examples to test with:

https://github.com/OpenSourceBrain/ghk-nernst

Check if test on [Ca2+]->0 is needed in SK_E2

See original mod:
https://github.com/OpenSourceBrain/L5bPyrCellHayEtAl2011/blob/master/neuroConstruct/cellMechanisms/SK_E2_mod/SK_E2.mod

Condition if(ca < 1e-7) is not checked in ChannelML.