opensourcebrain/purkinjecell

GitHub repository for an OSB project containing a cerebellar Purkinje cell based on De Schutter & Bower 1994

purkinjecell's Issues

Table discretisation for Ca dependence in KC channel

There is an issue with the table discretisation for the dependence of the KC channel conductance on [Ca2+] in the original GENESIS version of this model. See here for the script to create this channel.

More details... (Arnd, please add...)

This was discovered by Arnd Roth, Volker Steuber and Jenny Davie when converting the model from GENESIS to NEURON. This issue is illustrated by the different implementations of this channel in NEURON's NMODL format for the channel model with the incorrect table discretisation and one with a better, continuous calculation of the Ca dependence

NeuroML v2 versions of channels?

Are there NML v2 versions of the channels somewhere? I could not find them in this project, and the converter resulted in files with "Not yet implemented" message. Are there any plans to support such conversion somewhere?

Details below:
generatedNeuroML2 folder only has the leak channel.

Using the ChannelMLConvert converter on e.g. this .xml channel file (or other channel files), results in an .nml file with "Not implemented yet" instead of gating dynamics.

It seems that the converter has problems with the current_voltage_relation construct seen on this line.

CC: @scrook