VMUX is a Skype/Hangouts alternative that runs in the browser. It's built on top of WebRTC so you don't need to install any plugins or use Flash. You can do one-to-one or multi-party video calls and all the communications are P2P and encrypted.
You can use it at https://vmux.co
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VMUX works on the lastest stable versions of Chrome, Chrome for Android, Firefox, Firefox for Android and Opera.
For more info about WebRTC browser support go to WebRTC.org.
Prerequisite: Redis
If you already have a working Node/NPM environment, should be as easy as:
npm install
gulp
npm start
Point your browser to localhost:5000
If you're going to run VMUX in production, make sure you create your own Twitter app for authentication and it's configured properly.
VMUX is released under the BSD license.