ENTWINE
ENTWINE is a software (coded in C) to simulate a model of gene regulation and development that is abstract enough to allow for developmental noise, epistasis, pleiotropy, plasticity and other genetic mechanisms to arise realistically as a consequence of the network of gene interaction. By bringing together both the evolutionary perspective with the molecular perspectives of plastic responses, ENTWINE’s philosophy is rooted within the field of integrative biology.
Sorry, there is no manual!
Author
The main author is Jeremy A. Draghi. I (Remi Matthey-Doret) only made a few modifications in order to improve performance as well as in order to allow implementation of temporal environmental heteroogeneity as well as pllastic responses in responose to a performance signal.