Comments (2)
Hi,
Apologies for the late reply!
There is a resource of cytokine induced transcriptional signatures, called CytoSig. The predictive power is much lower than in case of TF or pathway activities. I'm sure alternative methods exist or are in development. I recommend to read the papers and docs of LIANA and ask my colleague @dbdimitrov who is expert on these methods.
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OmniPath's PPI network can be used to find downstream TFs in a sign-coherent way, see fig 4 here: https://www.biorxiv.org/content/10.1101/2023.08.19.553863v1
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