structuralgenomicsconsortium Goto Github PK

about_open_chem_networks

About the SGC's Open Chemistry Networks Initiative, and News

aircheck-documentation

Internal documentation for the AIRCHECK DEL project

chemistry_techops_howto

How to do things in the SGC's Chemistry Projects

cnp1-pkis-5

cnp10-chikv-naphthoquinone

An Open Chemistry Network dedicated to finding hits vs CHIKV based on a hit containing an naphthoquinone.

cnp11-denvrdrp-lifechem

An SGC Chemical Networks Project devoted to the DENV Rdrp, focusing specifically on exploring the LifeChemicals library. Use the link below to learn about our other READDI-AViDD projects.

cnp12-nsp15-tamu

hello

cnp13_rbbp4_pf_ortho

A descriptive page for biological characterisation and development of hits vs Pfal RBBP4 orthologue

cnp14-wdr91

cnp15-solubility-analysis

cnp16-iminoquinone-sarsrdrp-mechanstic-study

cnp17-denvrdrp-enaminecovalent

An SGC Chemical Networks Project devoted to the DENV Rdrp, focusing specifically on exploring the Enamine covalent library. Use the link below to learn about other READDI-AViDD projects.

cnp18-denvrdrp-virtualscreen

An SGC Chemical Networks Project devoted to the DENV Rdrp, focusing specifically on the results from a virtual screening campaign of the Enamine REAL space to identify hits. Use the link below to learn about other READDI-AViDD projects.

cnp19-chikvhelicase-covalent

An SGC Open Chemistry Networks Project (number 19) dedicated to finding hits vs CHIKV nsp2 helicase based on a HTS of a Enamine Covalent library.

cnp2-rbbp4

An SGC Chemical Networks Project Devoted to the target RBBP4

cnp20-chikvhelicase-virtualscreen

An SGC Open Chemistry Networks Project (number 20) dedicated to finding hits vs CHIKV nsp2 helicase based on a Virtual Screen of Enamine REAL compounds.

cnp21-chikvhelicase-asinex

An SGC Open Chemistry Networks Project (number 21) dedicated to finding hits vs CHIKV nsp2 helicase based on a HTS of a Asinex library.

cnp22-chikv-nsp2-protease

This project aims to develop new CHICKV NSP2 protease inhibitors with high potency and selectivity as well as with an improved physicochemical properties.

cnp23-sars-cov2-rdrp

cnp24-nsp10_14-frags

This project aims to develop potent inhibitors of NSP14/NSP10 for the treatment of (CoV-19), Targeting the NSP14 and NSP10 interacting interface with small molecules or peptides could be a smart strategy to obstruct replication processes of coronaviruses (CoVs).

cnp25-chikv-nsp3-macrodomain

This project aims to develop a chemical probe of CHIKV-nsP3-macrodomain starting from a fragment screen

cnp26_denvrdrp_referencecmpds

An SGC Chemical Networks Project devoted to the DENV Rdrp, focusing specifically on identifying a DENV reference compound. If you would like to learn about other repositories in the READDI-AViDD pipeline, please use the link below.

cnp27-sars-cov-2-nsp14

This project aims to develop a chemical probe of SARS-CoV2-NSP14 starting from a fragment screen

cnp28-nsp13-diamine-core

cnp29_chikvnsp2_del-ml

An SGC Open Chemistry Networks Project (number 29) dedicated to finding hits vs CHIKV nsp2 helicase based on a DEL screen and subsequent machine learning by X-Chem.

cnp3-hipk4

An SGC Chemical Networks Project Devoted to the Target HIPK4

cnp30_sars-cov-2_nsp13-helicase_brr2

cnp31_chikv-nsp2-protease_covalent

This project aims to develop potent covalent inhibitors of CHIKV nsP2 Protease for treatment against alphaviruses.

cnp32_sars-cov-2_nsp13-helicase_thiazoles

SARS-CoV-2 NSP13 helicase inhibitors development campaign based on pritelivir

cnp33_sars-cov-2_nsp12-rdrp_hts

SARS-CoV-2 nsP12 RdRp inhibitor development campaign by HTS