zaoqu-liu/irls

Machine learning-based integrative analysis develops an immune-derived lncRNA signature for improving clinical outcomes in colorectal cancer

irls's Issues

Question about model integration

Thanks for the great work first, which inspired me a lot. I read methods and supplementary methods. However I find little information about integration steps of two models. I notice there are only codes with "StepCox+survival-svm" in "Machine Learning based intergration.R", under the title "3-8.StepCox+gbm", which makes me confused. Would you like to share more details about how to integrate two models, such as RSF+Enet , coxBoost + survival-SVM ? Thank you very much for sharing.

Hope to get more details

Hi, I am very very interested in your literature, especially the integrated machine learning part. It is surprising for me. I also want to reproduce it to complete my graduation dissertation, but after watching your code base, I found that some input files are not provided.What a pity! I can't know the input format, so I am writing this letter hoping to get the model-step.Rda file.If it would be convenient , please send the file to my email [[email protected]]! Of courese.Whether you want to share or not, still thank you very much for your selfless and generous code

If the data is confidential, you can consider giving me the data format, or you can delete some important data, please, this is really really helpful for me! Thank you very much!

Hope to get more details

Hi, I am very interested in your literature, especially the integrated machine learning part. I also want to reproduce it to complete my graduation dissertation, but after watching your code base, I found that some input files are not provided.What a pity! I can't know the input format, so I am writing this letter hoping to get the model-step.Rda file.If it would be convenient , please send the file to my email [email protected]!
Of courese.Whether you want to share or not, still thank you very much for your selfless and generous code

Exact IRLS score values

Hi, is it possible to share the IRLS scores calculated for each case in the TCGA_CRC cohort? Thanks!

Hope to know exact regression coefficients

Hi, I am very interested in your literature. We are doing similar work and hope to compare the performance of signatures have been developed, include yours. However, we donnot know exact regression coefficients of 16 lncRNA in your model (Fig. 2C of your literature).
If it is possible could you share this data? Whether you want to share or not, still thank you very much.

How to calculate the IRLS

Hello, could you please share the code for calculating the IRLS for each sample?

how to download and install ImmuLncRNA package in R ？

data lost

could you share the ‘all-signature.rda'， ‘TCGA.rda’ and ‘model-step.Rda’，so that we can run it well?

could you please share me 'all-signature rda', you are my hero

my email
[email protected]